Find your collective agreement and other relevant documents. Frequent questions and instructions to understand your collective agreement. Consistent with the endocannabinoid hypothesis as endogenous substances limiting tumor growth, one study showed that AEA and other acylethanolamides such as OAS, PEA and stearoylethanolamide (SEA) were at lower concentrations in meningiomas and gliomas compared to healthy tissues (Maccarrone, Attina, Cartoni, Bari, Finazzi-Agré, 2001). This finding was supported by a study that reported a decrease in AEA levels in gliomas vs. nontumors (Wu et al., 2012). However, in this latest study, it was found that tissues with high-quality gliomas contained more AEA than the lower sections, and 2-AG appeared to be highly regulated in healthy Gliom tissues. An increase in AEA levels has been observed in hepatocellular carcinoma vs. tumor-free tissue (Mukhopadhyay et al., 2015). In addition, concentrations of AEA and 2-AG were highly regulated in relation to healthy mucous membranes (Ligresti et al., 2003) in human meningiomen (Petersen et al., 2005), as well as in polyps and colour-ecting carcinomas. In addition, analyses of lipid extracts from endometrial cancers revealed an overregulation of 2-AG compared to biopsies of healthy patients, while AEA and AEP remained virtually unchanged (Guida et al., 2010).
Finally, endocannabinoid upregulation has been demonstrated for prostate cancer (Nithipatikom et al., 2004; Schmid, would, Krebsbach, Berdyshev, Schmid, 2002), Hypophysenadenome (Pagotto et al., 2001) and colon cancerous tissue (Chen et al., 2015). Frank Kohlberger, Fuerster, Vice-President, 250-371-6557 The most recent terms agreed by the province and the B.C. Government and Service Employees` Union (BCGEU): on this page you will find everything you need to know about the BPL collective agreement. Information on the collective bargaining process (requires a member connection). ETO Changes – What you need to know: Information Video This compressed information video provides a brief overview of the steps needed to implement the new working language in the ETO component agreement. This video is only used for training purposes. ETO Hours of Work Joint Training Video BCGEU and BCPSA jointly developed training on new hours of work in the ETO component agreement and then provided this training to ETO employees across the province. This video is a recording of the Kamloops workout. It should only be considered for training purposes. On the other hand, the above pattern of AEA-Downregulation and increased levels of 2-AG in cancerous tissue, as published for Gliome (Wu et al., 2012), could be confirmed in analyses of circulating endocannabinoids.